Viagra Professional Dosage
Viagra professional (sildenafil) is a widely known medicine applied for treatment of impotence. This medication is available in tablets intended for oral administration, and it requires a written prescription. Sildenafil possesses a strong stimulating effect, ensuring a hard and stable erection. The drug belongs to the group of phosphodiestrase V inhibitors. Phosphodiestrase V (PDE5) is a natural enzyme, which controls the penile muscle and restricts blood flow to the corpus cavernosa (penile chambers). Sildenafil blocks this enzyme and stimulates the release of cyclic guanosine monophosphate (cGMP), which loosens the muscle and improves blood flow to the muscle and the chambers and thus provides better erection. It is also noteworthy that the production of cGMP is stimulated by the release of the nitric oxide into penile tissues, which only happens during sexual excitement. Therefore, Viagra's work is only observable in a state of sexual arousal.
Viagra Professional is sold in blue tablets, which contain 25, 50 or 100 mg of sildenafil citrate. If you feel like you cannot deal with your problem without sildenafil, you should turn to your physician, who will help you outline your individual dosage. This will depend on your general health, sensitivity to medical ingredients, and the severity of your disorder. For healthy people, the recommended starting dose is 50 mg. Once your doctor has appointed a dose, keep to it for a while to see how it works for you. If you think this is not enough for you, you may increase your daily dose. If you have negative side effects, you may have to reduce the dose or stop taking the drug.
A 50-mg daily dose is quite optimal for people dealing with mild cases of hepatic impairment or renal insufficiency. For people dealing with moderate or severe cases of these disorders, the dosage should be restricted to 25 mg. Sometimes, these conditions require thorough examinations involving blood tests and urine samples, in order to define the clearance rate. In these cases, dosage must be determined with due consideration of sildenafil metabolization, which may require a complicated and prolonged examination. Particular attention should be paid to dosage, if Viagra Professional is used along with other enzyme inhibitors, particularly CYP3A4 inhibitors, which take direct part in sildenafil metabolization and therefore may affect clearance. Poor clearance will result in high sildenafil plasma levels, which increase the risk of adverse reactions.
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