Viagra Contraindications
Viagra (Sildenafil) is one of the most commonly used ED drugs, and it is readily available on the pharmaceutical market. The drug is renowned for its enhancing aptitude, and many men who suffer erectile disorders resort to it. Sildenafil is a prescription drug, and it is not for everyone. It has quite a complicated mechanism of action, and in some cases, it can affect other bodily functions.
Viagra's action consists in the inhibition of the photodiestrase type 5, a natural enzyme that keeps the penile muscle strained and therefore hampers blood flow to the corpus cavernosum. At the same time, during sexual arousal, the concentration of cyclic guanosine monophosphate (cGMP) increases in the corpus cavernosum. Cyclic GMP contributes to the relaxation of the muscle and therefore improves blood supply. By blocking PDE5, Viagra increases the proportional amount of cGMP and thus feeds erection.
Sildenafil is known to potentiate hypotension, especially if used together with nitrates and nitrites, which are mostly used to treat heart problems. These drugs have strong hypotensive effects themselves, and concomitant use of Viagra and these medicines can cause a sudden drop in supine blood pressure. This may cause sudden faintness, dizziness and even loss of consciousness. Therefore, Viagra is a taboo for people suffering cardiovascular diseases, such as heart insufficiency, arrhythmia, infarction, coronary artery disease, or those who have recently undergone treatment with nitrates or nitrites.
Because Sildenafil is partially cleared in the urine, there may be an increase in Sildenafil plasma levels in people dealing with severe cases of renal insufficiency. For this reason, it is not advisable to use Viagra for men with serious kidney problems. Clinical research has not showed any change in Sildenafil plasma levels in men suffering mild or moderate renal insufficiency, as compared to healthy people.
For the most part, Viagra is metabolized by aid of liver enzymes. Therefore, people suffering hepatic impairment must regard this drug with caution. Hepatic insufficiency can lead to poor clearance of Sildenafil and hence high plasma levels.
Viagra tablets may contain 25mg, 50mg or 100mg of sildenafil citrate, and it is usually recommended to start with smaller doses. In any event, treatment requires professional assistance and supervision, and the whole strategy depends on how effective the course is and whether or not patients have any side effects, and how bad they are, if any.
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