Basic Information About Avandamet
Avandamet is an anti-diabetic drug which combines two powerful anti-diabetic drugs with different mechanisms of action: Rosiglitazone maleate, a member of the drug class of thiazolidinediones and Metformin hydrochloride, a member of the drug class of biguanides. Avandamet is worked out for treating non-insulin dependent diabetes (diabetes type 2). It is effective only under the condition that the function of the production of endogenous insulin is fulfilled by the pancreas, and therefore, Avandamet is essentially not for treating insulin-dependent diabetes.
Due to the combined properties of the two medications Avandamet is applied to improve glycemic control in patients suffering from diabetes type 2 who cannot improve their condition by diet alone or by taking one anti-diabetic agent. Essentially an anti-diabetic agent with the properties of the drug class of biguanides, Avandamet decreases the amount of glucose in the blood produced by the body, slows down its absorption in the digestive tract and enhances its utilization in peripheral tissues. At the same time as a thiazolidinedione containing Rosiglitazone, it enhances your body's sensitivity to the insulin in the main areas of insulin-resistance: adipose tissue, skeletal muscles and liver.
Usually Avandamet is prescribed for type 2 diabetes patients when anti-diabetic agents in the highest therapeutic doses do not bring the intended effect. In general combo therapies for patients suffering from type 2 diabetes have become acknowledged as an efficacious way to maintain good health of a person. The reason for it is that very often adult-onset diabetes is diagnosed pretty late when it has already developed and various complications of the disease have set in. It appears very difficult to establish long-term glycemic control and maintain a patient's condition within the compensation stage of diabetes. Due to its complex chemical composition Avandamet enables a diabetes sufferer to keep glucose levels within acceptable limits.
There are special conditions in which the intake of Avandamet is contraindicated. These conditions include kidney problems, metabolic acidosis including diabetic ketoacidosis, and liver dysfunction. It is recommended to temporary stop Avandamet if you are going to have an X-ray procedure with an injection of dyes in your vein. Avandamet should also be temporarily discontinued prior to surgeries, especially if they require restricted intake of food and fluids.
The dosage of Avandamet is fixed individually. You may take it irrespective of your meal time. But it is advisable to take Avandamet either with your meal or right after a meal to decrease the reactions of the digestive system which can be caused by Metformin. Any correction of the dose should be introduced taking into consideration the degree of the decrease in kidney function.
Avandamet, a representative of new medications, is bringing more options for diabetes care and more convenience to a diabetes sufferer. To get the beneficial long-lasting effect from Avandamet it is very important to combine taking it with exercises, weight control and proper dieting.